Nitisinone-Induced Keratopathy in Alkaptonuria Disease: A Case Report and Literature Review
Published: June 1, 2018 | DOI: https://doi.org/10.7860/JCDR/2018/35741.11629
Khalid Mousa Al Zubi, Mohammed Salem Alsbou, Mahmoud Hussein Alkhasawneh, Hani Mosleh Al-Shagahin
1. Assistant Professor, Special Surgery, Mutah University, Amman, Jordan.
2. Associate Professor, Pharmacology, Mutah University, Amman, Jordan.
3. Assistant Professor, Radiology, Mutah University, Amman, Jordan.
4 . Associate Professor, Special Surgery, Mutah University, AlKarak, Amman, Jordan.
Correspondence
Dr. Khalid Mousa Al Zubi,
Assistant Professor, Special Surgery, Mutah University, P.O.Box 1342, Amman, Jordan.
E-mail: dr_khalid zu@yahoo.com
We report a case of nitisinone-induced keratopathy in a 52-year-old male patient with Alkaptonuria (AKU) disease in Jordan. The patient presented with slight drop of left eye vision for the last four weeks, associated with a foreign body sensation in his left eye. On examination, it was found that his left eye vision was reduced to 6/12 and there were left dendrite-like corneal opacities in the left eye. He was given 10 mg of nitisinone per day, two years before his visual complaint. Three months following discontinuation of nitisinone, his visual acuity and corneal opacities disappeared completely. This is the fifth reported case of nitisinone-induced keratopathy, due to secondary tyrosinaemia in alkaptonuria.
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